| Protein Name | cholinergic receptor, nicotinic, alpha polypeptide 7 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 11441 |
| Gene Symbol | Chrna7 |
| UniProt | P49582 (ACHA7_MOUSE), Q53YJ9 (Q53YJ9_MOUSE), Q8CC01 (Q8CC01_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
464
Total Number of Articles : 931 |
Description |
cholinergic receptor, nicotinic, alpha polypeptide 7 |
| Gene Summary |
Enables acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including plasma membrane bounded cell projection organization; positive regulation of cell communication; and regulation of protein metabolic process. Acts upstream of or within several processes, including behavioral response to ethanol; learning or memory; and negative regulation of cytokine production. Located in apical plasma membrane; axolemma; and external side of plasma membrane. Is active in cholinergic synapse; postsynaptic specialization membrane; and presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; retina; and thymus. Used to study schizophrenia. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; esophagus squamous cell carcinoma; respiratory system cancer (multiple); and schizophrenia. Orthologous to several human genes including CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit). [provided by Alliance of Genome Resources, Jun 2025] |
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