Title : Protein kinase CK2 activates Nrf2 via autophagic degradation of Keap1 and activation of AMPK in human cancer cells.

Pub. Date : 2020 May

PMID : 32317087






1 Functional Relationships(s)
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1 In this study, Nrf2 overexpression attenuated CK2 downregulation-induced ROS production and senescence markers including SA-beta-gal staining and activation of p53-p21Cip1/WAF1 in human breast (MCF-7) and colon (HCT116) cancer cells. 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid NFE2 like bZIP transcription factor 2 Homo sapiens