Title : Karacoline, identified by network pharmacology, reduces degradation of the extracellular matrix in intervertebral disc degeneration via the NF-κB signaling pathway.

Pub. Date : 2020 Feb

PMID : 32123596






2 Functional Relationships(s)
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1 We therefore applied different concentrations of karacoline (0, 1.25, or 12.88 muM) along with 100 ng/mL TNF-alpha to rat nucleus pulposus cells and found that karacoline reduced the expression of MMP-14 in IDD by inhibiting the nuclear factor (NF)-kappaB pathway, while collagen II and aggrecan expression was increased. Karacoline matrix metallopeptidase 14 Rattus norvegicus
2 We therefore applied different concentrations of karacoline (0, 1.25, or 12.88 muM) along with 100 ng/mL TNF-alpha to rat nucleus pulposus cells and found that karacoline reduced the expression of MMP-14 in IDD by inhibiting the nuclear factor (NF)-kappaB pathway, while collagen II and aggrecan expression was increased. Karacoline matrix metallopeptidase 14 Rattus norvegicus