PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32123596-7 2020 We therefore applied different concentrations of karacoline (0, 1.25, or 12.88 muM) along with 100 ng/mL TNF-alpha to rat nucleus pulposus cells and found that karacoline reduced the expression of MMP-14 in IDD by inhibiting the nuclear factor (NF)-kappaB pathway, while collagen II and aggrecan expression was increased. Karacoline 49-59 matrix metallopeptidase 14 Rattus norvegicus 197-203 32123596-7 2020 We therefore applied different concentrations of karacoline (0, 1.25, or 12.88 muM) along with 100 ng/mL TNF-alpha to rat nucleus pulposus cells and found that karacoline reduced the expression of MMP-14 in IDD by inhibiting the nuclear factor (NF)-kappaB pathway, while collagen II and aggrecan expression was increased. Karacoline 160-170 tumor necrosis factor Rattus norvegicus 105-114 32123596-7 2020 We therefore applied different concentrations of karacoline (0, 1.25, or 12.88 muM) along with 100 ng/mL TNF-alpha to rat nucleus pulposus cells and found that karacoline reduced the expression of MMP-14 in IDD by inhibiting the nuclear factor (NF)-kappaB pathway, while collagen II and aggrecan expression was increased. Karacoline 160-170 matrix metallopeptidase 14 Rattus norvegicus 197-203