Pub. Date : 2020 Jan 10
PMID : 31924757
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1KO) reduces muscle mass. | Oxygen | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 2 | PHD1KO muscles show impaired mTORC1 activation in response to leucine whereas mTORC1 activation by growth factors or eccentric contractions was preserved. | Leucine | egl-9 family hypoxia-inducible factor 2 | Mus musculus |
| 3 | The ability of PHD1 to promote mTORC1 activity is independent of its hydroxylation activity but is caused by decreased protein content of the leucyl tRNA synthetase (LRS) leucine sensor. | Leucine | egl-9 family hypoxia-inducible factor 2 | Mus musculus |