Pub. Date : 2020 Feb 15
PMID : 31843644
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Biochemical characterization of mono ADP ribosyl transferase activity of human sirtuin SIRT7 and its regulation. | poly(ADP)-ribosylated proteins | sirtuin 7 | Homo sapiens |
| 2 | SIRT7 contains a conserved catalytic core with long flanking N- and C-terminal extensions. | Nitrogen | sirtuin 7 | Homo sapiens |
| 3 | SIRT7 contains a conserved catalytic core with long flanking N- and C-terminal extensions. | Carbon | sirtuin 7 | Homo sapiens |
| 4 | Mutation of certain residues at the active site suggests that mono ADP-ribosylation and deacetylation are two distinct activities of SIRT7. | Adenosine Diphosphate | sirtuin 7 | Homo sapiens |
| 5 | In this study, we also find that the SIRT7 enzyme can specifically transfer a single moiety of ADP ribose on other nuclear proteins, with a preference for NAD+. | Adenosine Diphosphate Ribose | sirtuin 7 | Homo sapiens |
| 6 | In this study, we also find that the SIRT7 enzyme can specifically transfer a single moiety of ADP ribose on other nuclear proteins, with a preference for NAD+. | NAD | sirtuin 7 | Homo sapiens |
| 7 | A comparison of these dual activities suggests SIRT7"s preference for the mono ADPr transfer over its deacetylation of H3K18Ac. | H-2K(K) antigen | sirtuin 7 | Homo sapiens |
| 8 | Finally, we can also relate SIRT7 to the DNA repair process through ADP ribosylation of one of its key players, PARP1. | Adenosine Diphosphate | sirtuin 7 | Homo sapiens |