Title : Cigarette smoke exposure induces ROS-mediated autophagy by regulating sestrin, AMPK, and mTOR level in mice.

Pub. Date : 2019 Dec

PMID : 30957679






2 Functional Relationships(s)
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1 Exposure to CS increased the production of ROS and induced molecular changes in the autophagy pathway, including an increase in phosphorylated AMPK and ULK1, reduction in phosphorylated mTOR, and increases in SESN2, ATG12, and LC3B levels. Cesium sestrin 2 Mus musculus
2 In conclusion, these results suggest the involvement of ROS, SESN2, AMPK, and mTOR in the CS-induced autophagic process in the lung. Cesium sestrin 2 Mus musculus