| Protein Name | sestrin 2 |
|---|---|
| Organism | Mus musculus |
| Gene ID | 230784 |
| Gene Symbol | Sesn2 |
| UniProt | P58043 (SESN2_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
60
Total Number of Articles : 49 |
Description |
sestrin 2 |
| Gene Summary |
Enables GDP-dissociation inhibitor activity and PH domain binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of TORC1 signaling; and negative regulation of translation in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including D-glucose import; positive regulation of metabolic process; and regulation of intracellular signal transduction. Part of TORC2 complex and nucleotide-activated protein kinase complex. Is expressed in central nervous system; heart; and retina. Orthologous to human SESN2 (sestrin 2). [provided by Alliance of Genome Resources, Jul 2025] |
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| Properties | |