Title : Robenacoxib in the treatment of pain in cats and dogs: safety, efficacy, and place in therapy.

Pub. Date : 2018

PMID : 30148083






2 Functional Relationships(s)
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1 This review initially focuses on the preclinical pharmacology of robenacoxib in rats that includes its high affinity for COX-2 enzyme and weaker and rapidly reversible binding for COX-1 enzyme in in vitro and ex vivo models of inflammation and its pharmacokinetics in the blood and inflammatory exudate, selective tissue distribution, and safety. robenacoxib prostaglandin-endoperoxide synthase 2 Rattus norvegicus
2 This review initially focuses on the preclinical pharmacology of robenacoxib in rats that includes its high affinity for COX-2 enzyme and weaker and rapidly reversible binding for COX-1 enzyme in in vitro and ex vivo models of inflammation and its pharmacokinetics in the blood and inflammatory exudate, selective tissue distribution, and safety. robenacoxib cytochrome c oxidase I, mitochondrial Rattus norvegicus