PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30148083-4 2018 This review initially focuses on the preclinical pharmacology of robenacoxib in rats that includes its high affinity for COX-2 enzyme and weaker and rapidly reversible binding for COX-1 enzyme in in vitro and ex vivo models of inflammation and its pharmacokinetics in the blood and inflammatory exudate, selective tissue distribution, and safety. robenacoxib 65-76 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 121-126 30148083-4 2018 This review initially focuses on the preclinical pharmacology of robenacoxib in rats that includes its high affinity for COX-2 enzyme and weaker and rapidly reversible binding for COX-1 enzyme in in vitro and ex vivo models of inflammation and its pharmacokinetics in the blood and inflammatory exudate, selective tissue distribution, and safety. robenacoxib 65-76 cytochrome c oxidase I, mitochondrial Rattus norvegicus 180-185