Protein Name prostaglandin-endoperoxide synthase 2
Organism Rattus norvegicus
Gene ID 29527
Gene Symbol


UniProt P35355 (PGH2_RAT)
Relationships Total Number of functionally related compound(s) : 1161
Total Number of Articles : 2070

prostaglandin-endoperoxide synthase 2

Gene Summary

Enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and positive regulation of cytokine production. Acts upstream of or within bone mineralization. Located in cytoplasm. Part of protein-containing complex. Colocalizes with caveola. Used to study several diseases, including Barrett's esophagus; brain disease (multiple); hypertension (multiple); lung disease (multiple); and neurodegenerative disease (multiple). Biomarker of several diseases, including carcinoma (multiple); glioblastoma (multiple); inflammatory bowel disease (multiple); pleurisy; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); avian influenza; cardiovascular system disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human PTGS2 (prostaglandin-endoperoxide synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

  • prostaglandin G/H synthase 2
  • PGH synthase 2
  • cyclooxygenase-2
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