Title : TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes.

Pub. Date : 2018 Feb 5

PMID : 29395922






2 Functional Relationships(s)
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1 Upon axon injury, the SARM1 TIR domain cleaves nicotinamide adenine dinucleotide (NAD+), destroying this essential metabolic co-factor to trigger axon destruction [11, 12]. NAD sterile alpha and TIR motif containing 1 Homo sapiens
2 Upon axon injury, the SARM1 TIR domain cleaves nicotinamide adenine dinucleotide (NAD+), destroying this essential metabolic co-factor to trigger axon destruction [11, 12]. NAD sterile alpha and TIR motif containing 1 Homo sapiens