Title : Cytotoxic effects of gastrodin extracted from the rhizome of Gastrodia elata Blume in glioblastoma cells, but not in normal astrocytes, via the induction of oxidative stress-associated apoptosis that involved cell cycle arrest and p53 activation.

Pub. Date : 2017 Sep

PMID : 28689919






5 Functional Relationships(s)
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1 In DBTRG-05MG cells but not in CTX TNA2 cells, gastrodin (20-30 muM) induced cytotoxicity, G2/M phase cell cycle arrest and apoptosis. gastrodin latexin Homo sapiens
2 Regarding oxidative stress, gastrodin (20-30 muM) elevated intracellular ROS levels but reduced GSH levels. gastrodin latexin Homo sapiens
3 Treatment with the antioxidant NAC (10 muM) partially reversed gastrodin-altered antioxidant enzymes levels. gastrodin synuclein alpha Homo sapiens
4 Treatment with the antioxidant NAC (10 muM) partially reversed gastrodin-altered antioxidant enzymes levels. gastrodin latexin Homo sapiens
5 The apoptotic effects evoked by gastrodin were partially inhibited by the antioxidant NAC and the pancaspase inhibitor Z-VAD-FMK. gastrodin synuclein alpha Homo sapiens