Protein Name synuclein alpha
Organism Homo sapiens
Gene ID 6622
Gene Symbol


UniProt P37840 (SYUA_HUMAN), H6UYS5 (H6UYS5_HUMAN)
Relationships Total Number of functionally related compound(s) : 1780
Total Number of Articles : 3241

synuclein alpha

Gene Summary

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

  • alpha-synuclein
  • I+/--synuclein
  • non A-beta component of AD amyloid
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