| Protein Name | synuclein alpha |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 6622 |
| Gene Symbol | SNCA |
| UniProt | P37840 (SYUA_HUMAN), H6UYS5 (H6UYS5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
1780
Total Number of Articles : 3241 |
Description |
synuclein alpha |
| Gene Summary |
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016] |
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| Properties | |