Pub. Date : 2016 Dec 1
PMID : 27906185
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anti-proliferative activity of the NPM1 interacting natural product avrainvillamide in acute myeloid leukemia. | avrainvillamide | nucleophosmin 1 | Homo sapiens |
| 2 | Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome region maintenance 1 homolog (CRM1) interacting natural product avrainvillamide (AVA) and a fully syntetic AVA analog. | avrainvillamide | nucleophosmin 1 | Homo sapiens |
| 3 | Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome region maintenance 1 homolog (CRM1) interacting natural product avrainvillamide (AVA) and a fully syntetic AVA analog. | avrainvillamide | exportin 1 | Homo sapiens |
| 4 | Here we examined the in vitro and in vivo anti-leukemic activity of the NPM1 and chromosome region maintenance 1 homolog (CRM1) interacting natural product avrainvillamide (AVA) and a fully syntetic AVA analog. | avrainvillamide | exportin 1 | Homo sapiens |
| 5 | AVA treatment induced nuclear retention of the NPM1 mutant protein (NPMc+) in OCI-AML3 cells and primary AML cells, caused proteasomal degradation of NPMc+ and the nuclear export factor CRM1 and downregulated wt FLT3 protein. | avrainvillamide | nucleophosmin 1 | Homo sapiens |
| 6 | AVA treatment induced nuclear retention of the NPM1 mutant protein (NPMc+) in OCI-AML3 cells and primary AML cells, caused proteasomal degradation of NPMc+ and the nuclear export factor CRM1 and downregulated wt FLT3 protein. | avrainvillamide | exportin 1 | Homo sapiens |
| 7 | AVA treatment induced nuclear retention of the NPM1 mutant protein (NPMc+) in OCI-AML3 cells and primary AML cells, caused proteasomal degradation of NPMc+ and the nuclear export factor CRM1 and downregulated wt FLT3 protein. | avrainvillamide | fms related receptor tyrosine kinase 3 | Homo sapiens |