Pub. Date : 2016 Oct 24
PMID : 27775054
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Thromboxane A2 receptor antagonist SQ29548 reduces ischemic stroke-induced microglia/macrophages activation and enrichment, and ameliorates brain injury. | SQ 29548 | thromboxane A2 receptor | Mus musculus |
| 2 | We have previously shown that TXA2R antagonist SQ29548 attenuates BV2 microglia activation by suppression of ERK pathway, but its effect is not tested in vivo. | SQ 29548 | thromboxane A2 receptor | Mus musculus |
| 3 | We have previously shown that TXA2R antagonist SQ29548 attenuates BV2 microglia activation by suppression of ERK pathway, but its effect is not tested in vivo. | SQ 29548 | mitogen-activated protein kinase 1 | Mus musculus |
| 4 | Administration of SQ29548 inhibited microglia/macrophages activation and enrichment, including both M1 and M2 phenotypes, and attenuated ischemia-induced IL-1ss, IL-6, and TNF-alpha up-regulation and iNOS release. | SQ 29548 | interleukin 1 complex | Mus musculus |
| 5 | Administration of SQ29548 inhibited microglia/macrophages activation and enrichment, including both M1 and M2 phenotypes, and attenuated ischemia-induced IL-1ss, IL-6, and TNF-alpha up-regulation and iNOS release. | SQ 29548 | interleukin 6 | Mus musculus |
| 6 | Administration of SQ29548 inhibited microglia/macrophages activation and enrichment, including both M1 and M2 phenotypes, and attenuated ischemia-induced IL-1ss, IL-6, and TNF-alpha up-regulation and iNOS release. | SQ 29548 | tumor necrosis factor | Mus musculus |
| 7 | TXA2R antagonist SQ29548 inhibited ischemia-induced inflammatory response and furthermore reduced microglia/macrophages activation and ischemic/reperfusion brain injury. | SQ 29548 | thromboxane A2 receptor | Mus musculus |