Pub. Date : 2016 Aug 4
PMID : 27536732
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using a human-to-mouse approach, we next showed a similar enzymatic increase in two well-validated IBD murine models and evaluated the therapeutic effect of the potent FOLH1/ GCPII inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) (IC50 = 300 pM). | 2-(phosphonomethyl)pentanedioic acid | folate hydrolase 1 | Mus musculus |
| 2 | Using a human-to-mouse approach, we next showed a similar enzymatic increase in two well-validated IBD murine models and evaluated the therapeutic effect of the potent FOLH1/ GCPII inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) (IC50 = 300 pM). | 2-(phosphonomethyl)pentanedioic acid | folate hydrolase 1 | Mus musculus |
| 3 | In the dextran sodium sulfate (DSS) colitis model, 2-PMPA inhibited the GCPII activity in the colonic mucosa by over 90% and substantially reduced the disease activity. | 2-(phosphonomethyl)pentanedioic acid | folate hydrolase 1 | Homo sapiens |
| 4 | In the murine IL-10-/- model of spontaneous colitis, daily 2-PMPA treatment also significantly reduced both macroscopic and microscopic disease severity. | 2-(phosphonomethyl)pentanedioic acid | interleukin 10 | Mus musculus |