PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27536732-4	2016	Using a human-to-mouse approach, we next showed a similar enzymatic increase in two well-validated IBD murine models and evaluated the therapeutic effect of the potent FOLH1/ GCPII inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) (IC50 = 300 pM).	2-(phosphonomethyl)pentanedioic acid	191-226	folate hydrolase 1	Mus musculus	168-173	
27536732-4	2016	Using a human-to-mouse approach, we next showed a similar enzymatic increase in two well-validated IBD murine models and evaluated the therapeutic effect of the potent FOLH1/ GCPII inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) (IC50 = 300 pM).	2-(phosphonomethyl)pentanedioic acid	191-226	folate hydrolase 1	Mus musculus	175-180	
27536732-5	2016	In the dextran sodium sulfate (DSS) colitis model, 2-PMPA inhibited the GCPII activity in the colonic mucosa by over 90% and substantially reduced the disease activity.	2-(phosphonomethyl)pentanedioic acid	51-57	folate hydrolase 1	Homo sapiens	72-77	
27536732-7	2016	In the murine IL-10-/- model of spontaneous colitis, daily 2-PMPA treatment also significantly reduced both macroscopic and microscopic disease severity.	2-(phosphonomethyl)pentanedioic acid	59-65	interleukin 10	Mus musculus	14-19