Pub. Date : 2016
PMID : 26934053
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using mice exposed to THS under conditions that mimic exposure of humans, we show that THS increases cellular oxidative stress by increasing superoxide dismutase (SOD) activity and hydrogen peroxide (H2O2) levels while reducing the activity of antioxidant enzymes catalase and glutathione peroxidase (GPx) that break down H2O2 into H2O and O2. | THYMIDINE-5'-(DITHIO)PHOSPHATE | catalase | Homo sapiens |
| 2 | To determine whether these effects on THS-induced insulin resistance are due to increase in oxidative stress, we treated mice exposed to THS with the antioxidants N-acetyl cysteine (NAC) and alpha-tocopherol (alpha-toc) and showed that the oxidative stress, the molecular damage, and the insulin resistance, were significantly reversed. | THYMIDINE-5'-(DITHIO)PHOSPHATE | insulin | Homo sapiens |
| 3 | In conclusion, THS exposure results in insulin resistance in the form of non-obese type II diabetes (NODII) through oxidative stress. | THYMIDINE-5'-(DITHIO)PHOSPHATE | insulin | Homo sapiens |