Protein Name BCL2 antagonist/killer 1
Organism Homo sapiens
Gene ID 578
Gene Symbol


UniProt Q16611 (BAK_HUMAN), A0A0S2Z391 (A0A0S2Z391_HUMAN)
Relationships Total Number of functionally related compound(s) : 490
Total Number of Articles : 694

BCL2 antagonist/killer 1

Gene Summary

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008]

  • bcl-2 homologous antagonist/killer
  • BCL2-like 7 protein
  • apoptosis regulator BAK
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