| Protein Name | BCL2 antagonist/killer 1 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 578 |
| Gene Symbol | BAK1 |
| UniProt | Q16611 (BAK_HUMAN), A0A0S2Z391 (A0A0S2Z391_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
490
Total Number of Articles : 694 |
Description |
BCL2 antagonist/killer 1 |
| Gene Summary |
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. [provided by RefSeq, Jul 2008] |
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