Pub. Date : 2014 Nov
PMID : 25122779
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To test this hypothesis, we generated cell lines for doxycycline-inducible expression of short hairpin RNAs (shRNAs) targeting the PI4P effector, four-phosphate adaptor protein 2 (FAPP2). | Doxycycline | pleckstrin homology domain containing A8 | Homo sapiens |
| 2 | To test this hypothesis, we generated cell lines for doxycycline-inducible expression of short hairpin RNAs (shRNAs) targeting the PI4P effector, four-phosphate adaptor protein 2 (FAPP2). | Doxycycline | pleckstrin homology domain containing A8 | Homo sapiens |
| 3 | We also found that HCV significantly increases the level of some glycosphingolipids, whereas adding these lipids to FAPP2-depleted cells partially rescued replication, further arguing for the importance of glycosphingolipids in HCV RNA synthesis. | Glycosphingolipids | pleckstrin homology domain containing A8 | Homo sapiens |
| 4 | Altogether, our study implies that HCV coopts FAPP2 for virus genome replication via PI4P binding and glycosphingolipid transport to the HCV RC. | Glycosphingolipids | pleckstrin homology domain containing A8 | Homo sapiens |