Title : Suicide inactivation of cytochrome P-450 by methoxsalen. Evidence for the covalent binding of a reactive intermediate to the protein moiety.

Pub. Date : 1989 Sep

PMID : 2506333






3 Functional Relationships(s)
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1 Incubation of rat liver microsomes with [3H]methoxsalen and NADPH resulted in the covalent binding of a methoxsalen intermediate to proteins comigrating with cytochromes P-450 UT-A, PB-B/D, ISF-G and PCN-E. [3h]methoxsalen cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
2 Incubation of rat liver microsomes with [3H]methoxsalen and NADPH resulted in the covalent binding of a methoxsalen intermediate to proteins comigrating with cytochromes P-450 UT-A, PB-B/D, ISF-G and PCN-E. NADP cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus
3 Incubation of rat liver microsomes with [3H]methoxsalen and NADPH resulted in the covalent binding of a methoxsalen intermediate to proteins comigrating with cytochromes P-450 UT-A, PB-B/D, ISF-G and PCN-E. Methoxsalen cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus