Title : Inhibitory effect of chlordecone and mirex on steroid synthesis in Y-1 cells.

Pub. Date : 1987 Mar-Apr

PMID : 2439679






2 Functional Relationships(s)
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1 Technical grade chlordecone produced a dose-dependent inhibition of steroidogenesis in cultured mouse adrenal tumor cells (Y-1 cells) when stimulated with ACTH (IC50 = 4 X 10(-5) M), cAMP (IC50 = 2.3 X 10(-5) M), or pregnenolone (IC50 3.5 X 10(-5) M). Chlordecone pro-opiomelanocortin-alpha Mus musculus
2 Technical grade chlordecone produced a dose-dependent inhibition of steroidogenesis in cultured mouse adrenal tumor cells (Y-1 cells) when stimulated with ACTH (IC50 = 4 X 10(-5) M), cAMP (IC50 = 2.3 X 10(-5) M), or pregnenolone (IC50 3.5 X 10(-5) M). Chlordecone cathelicidin antimicrobial peptide Mus musculus