Protein Name pro-opiomelanocortin-alpha
Organism Mus musculus
Gene ID 18976
Gene Symbol


UniProt P01193 (COLI_MOUSE)
Relationships Total Number of functionally related compound(s) : 1024
Total Number of Articles : 1550


Gene Summary

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing. Processing yields several biologically active peptides, which are involved in diverse cellular functions, such as energy homeostasis, steroidogenesis, and increased melanin production in melanocytes. In mouse deficiency of this gene is associated with obesity, defects in adrenal development, and altered pigmentation. A pseudogene of this gene is located on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

  • pro-opiomelanocortin
  • adrenal corticotropic hormone
  • adrenocorticotropic hormone
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