Pub. Date : 2014 Sep
PMID : 23775171
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rutaecarpine inhibits angiotensin II-induced proliferation in rat vascular smooth muscle cells. | rutecarpine | angiotensinogen | Rattus norvegicus |
| 2 | OBJECTIVE: To evaluate the effects and possible mechanisms of rutaecarpine on angiotensin II (Ang II)-induced proliferation in cultured rat vascular smooth muscle cells (VSMCs). | rutecarpine | angiotensinogen | Rattus norvegicus |
| 3 | OBJECTIVE: To evaluate the effects and possible mechanisms of rutaecarpine on angiotensin II (Ang II)-induced proliferation in cultured rat vascular smooth muscle cells (VSMCs). | rutecarpine | angiotensinogen | Rattus norvegicus |
| 4 | RESULTS: Rutaecarpine (0.3-3.0 mumol/L) inhibited Ang II-induced VSMC proliferation and the best effects were achieved at 3.0 mumol/L. | rutecarpine | angiotensinogen | Rattus norvegicus |
| 5 | The Ang II-induced decreases in cellular NO contents and NOS activities were antagonized by rutaecarpine (P <0.05). | rutecarpine | angiotensinogen | Rattus norvegicus |
| 6 | CONCLUSION: Rutaecarpine is effective against Ang II-induced rat VSMC proliferation, and this effect is due, at least in part, to NO production and the modulation of VMSC proliferation-related gene expressions. | rutecarpine | angiotensinogen | Rattus norvegicus |