Pub. Date : 2013
PMID : 23745104
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1. | Cocaine | TIAM Rac1 associated GEF 1 | Rattus norvegicus |
| 2 | Here, we demonstrate that rats that actively self-administer cocaine display reduced levels of Tiam1 in the NAc. | Cocaine | TIAM Rac1 associated GEF 1 | Rattus norvegicus |
| 3 | We then examined the contribution of D1-MSNs to the cocaine-mediated decrease of Tiam1. | Cocaine | TIAM Rac1 associated GEF 1 | Rattus norvegicus |
| 4 | Moreover, inhibiting these NAc D1-MSNs during cocaine exposure reversed the down-regulation of Tiam1 gene expression and protein levels. | Cocaine | TIAM Rac1 associated GEF 1 | Rattus norvegicus |