Protein Name TIAM Rac1 associated GEF 1
Organism Rattus norvegicus
Gene ID 304109
Gene Symbol

Tiam1

UniProt -
Relationships Total Number of functionally related compound(s) : 12
Total Number of Articles : 10
Description

TIAM Rac1 associated GEF 1

Gene Summary

Enables microtubule binding activity and receptor tyrosine kinase binding activity. Involved in several processes, including activation of GTPase activity; positive regulation of neurogenesis; and regulation of MAPK cascade. Located in several cellular components, including axon; dendritic spine; and ruffle membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with language delay and seizures. Orthologous to human TIAM1 (TIAM Rac1 associated GEF 1). [provided by Alliance of Genome Resources, Jun 2025]

synonyms
  • rho guanine nucleotide exchange factor TIAM1
  • T-cell lymphoma invasion and metastasis 1
  • T-lymphoma invasion and metastasis-inducing protein 1
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Properties