PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23745104-0 2013 Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1. Cocaine 74-81 TIAM Rac1 associated GEF 1 Rattus norvegicus 105-110 23745104-5 2013 Here, we demonstrate that rats that actively self-administer cocaine display reduced levels of Tiam1 in the NAc. Cocaine 61-68 TIAM Rac1 associated GEF 1 Rattus norvegicus 95-100 23745104-9 2013 We then examined the contribution of D1-MSNs to the cocaine-mediated decrease of Tiam1. Cocaine 52-59 TIAM Rac1 associated GEF 1 Rattus norvegicus 81-86 23745104-11 2013 Moreover, inhibiting these NAc D1-MSNs during cocaine exposure reversed the down-regulation of Tiam1 gene expression and protein levels. Cocaine 46-53 TIAM Rac1 associated GEF 1 Rattus norvegicus 95-100