Pub. Date : 2013 May 2
PMID : 23510861
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Rutaecarpine administration induced Cyp1a2, 2b10 and 2e1 as previously reported. | rutecarpine | cytochrome P450, family 1, subfamily a, polypeptide 2 | Mus musculus |
| 2 | For phase-2 enzyme genes, rutaecarpine increased glucuronyltransferases (Ugt1a1 and Ugt1a6), but had no effects on sulfotransferase (Sult1a1 and Sult1b1). | rutecarpine | UDP glucuronosyltransferase 1 family, polypeptide A1 | Mus musculus |
| 3 | For phase-2 enzyme genes, rutaecarpine increased glucuronyltransferases (Ugt1a1 and Ugt1a6), but had no effects on sulfotransferase (Sult1a1 and Sult1b1). | rutecarpine | UDP glucuronosyltransferase 1 family, polypeptide A6A | Mus musculus |
| 4 | Most interestingly, rutaecarpine increased hepatic uptake of organic anion transporting peptides (Oatp1a1, Oayp1a4, Oatp1b2, and Oatp2b1) and induced efflux transporter such as multidrug resistance-associated proteins (Mrp1, Mrp2, Mrp3, and Mrp4), especially at the doses of 20mg/kg and above. | rutecarpine | solute carrier organic anion transporter family, member 1a1 | Mus musculus |
| 5 | Most interestingly, rutaecarpine increased hepatic uptake of organic anion transporting peptides (Oatp1a1, Oayp1a4, Oatp1b2, and Oatp2b1) and induced efflux transporter such as multidrug resistance-associated proteins (Mrp1, Mrp2, Mrp3, and Mrp4), especially at the doses of 20mg/kg and above. | rutecarpine | solute carrier organic anion transporter family, member 1b2 | Mus musculus |
| 6 | Most interestingly, rutaecarpine increased hepatic uptake of organic anion transporting peptides (Oatp1a1, Oayp1a4, Oatp1b2, and Oatp2b1) and induced efflux transporter such as multidrug resistance-associated proteins (Mrp1, Mrp2, Mrp3, and Mrp4), especially at the doses of 20mg/kg and above. | rutecarpine | chemokine (C-C motif) ligand 6 | Mus musculus |
| 7 | Most interestingly, rutaecarpine increased hepatic uptake of organic anion transporting peptides (Oatp1a1, Oayp1a4, Oatp1b2, and Oatp2b1) and induced efflux transporter such as multidrug resistance-associated proteins (Mrp1, Mrp2, Mrp3, and Mrp4), especially at the doses of 20mg/kg and above. | rutecarpine | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | Mus musculus |
| 8 | Most interestingly, rutaecarpine increased hepatic uptake of organic anion transporting peptides (Oatp1a1, Oayp1a4, Oatp1b2, and Oatp2b1) and induced efflux transporter such as multidrug resistance-associated proteins (Mrp1, Mrp2, Mrp3, and Mrp4), especially at the doses of 20mg/kg and above. | rutecarpine | prolactin family 2, subfamily c, member 4 | Mus musculus |
| 9 | Most interestingly, rutaecarpine increased hepatic uptake of organic anion transporting peptides (Oatp1a1, Oayp1a4, Oatp1b2, and Oatp2b1) and induced efflux transporter such as multidrug resistance-associated proteins (Mrp1, Mrp2, Mrp3, and Mrp4), especially at the doses of 20mg/kg and above. | rutecarpine | prolactin family 2, subfamily c, member 5 | Mus musculus |