Pub. Date : 2013
PMID : 23484006
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We therefore analyzed the effects of the c-MET- and VEGFR2 tyrosine kinase inhibitor cabozantinib (XL184, Exelixis) on c-MET positive orthotopic E98 glioblastoma xenografts, which routinely present with angiogenesis-dependent areas of tumor growth, as well as diffuse infiltrative growth. | cabozantinib | MET proto-oncogene, receptor tyrosine kinase | Homo sapiens |
| 2 | In in vitro cultures of E98 cells, cabozantinib effectively inhibited c-MET phosphorylation, concomitant with inhibitory effects on AKT and ERK1/2 phosphorylation, and cell proliferation and migration. | cabozantinib | MET proto-oncogene, receptor tyrosine kinase | Homo sapiens |
| 3 | In in vitro cultures of E98 cells, cabozantinib effectively inhibited c-MET phosphorylation, concomitant with inhibitory effects on AKT and ERK1/2 phosphorylation, and cell proliferation and migration. | cabozantinib | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | In in vitro cultures of E98 cells, cabozantinib effectively inhibited c-MET phosphorylation, concomitant with inhibitory effects on AKT and ERK1/2 phosphorylation, and cell proliferation and migration. | cabozantinib | mitogen-activated protein kinase 3 | Homo sapiens |
| 5 | Of importance, in contrast to the results from in vitro experiments, in vivo blockade of c-MET activation was incomplete, possibly due to multiple factors including restoration of the blood-brain barrier resulting from cabozantinib-induced VEGFR2 inhibition. | cabozantinib | MET proto-oncogene, receptor tyrosine kinase | Homo sapiens |
| 6 | Of importance, in contrast to the results from in vitro experiments, in vivo blockade of c-MET activation was incomplete, possibly due to multiple factors including restoration of the blood-brain barrier resulting from cabozantinib-induced VEGFR2 inhibition. | cabozantinib | kinase insert domain receptor | Homo sapiens |
| 7 | In conclusion, cabozantinib is a promising therapy for c-MET positive glioma, but improving delivery of the drug to the tumor and/or the surrounding tissue may be needed for full activity. | cabozantinib | MET proto-oncogene, receptor tyrosine kinase | Homo sapiens |