Title : Alveolar macrophages play a key role in cockroach-induced allergic inflammation via TNF-α pathway.

Pub. Date : 2012

PMID : 23094102






4 Functional Relationships(s)
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1 We determined whether the serine protease in German cockroach extract (GCE) enhances TNF-alpha production by alveolar macrophages through the PAR-2 pathway and whether the TNF-alpha production affects GCE-induced pulmonary inflammation. GCE complement component 1, s subcomponent 1 Mus musculus
2 We determined whether the serine protease in German cockroach extract (GCE) enhances TNF-alpha production by alveolar macrophages through the PAR-2 pathway and whether the TNF-alpha production affects GCE-induced pulmonary inflammation. GCE tumor necrosis factor Mus musculus
3 We determined whether the serine protease in German cockroach extract (GCE) enhances TNF-alpha production by alveolar macrophages through the PAR-2 pathway and whether the TNF-alpha production affects GCE-induced pulmonary inflammation. GCE pulmonary adenoma resistance 2 Mus musculus
4 Depletion of alveolar macrophages reduced AHR and intracellular TNF-alpha level in pulmonary cell populations in the GCE-induced asthma model. GCE tumor necrosis factor Mus musculus