Pub. Date : 2012 Oct 30
PMID : 22982592
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway. | gastrodin | mitogen activated protein kinase 3 | Rattus norvegicus |
| 2 | Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway. | gastrodin | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 3 | Pre-treatment of primary hippocampal neurons with gastrodin significantly attenuated Abeta(1-42)-induced neurotoxicity and changes in SOD and CAT, and upregulated gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation. | gastrodin | catalase | Rattus norvegicus |
| 4 | Pre-treatment of primary hippocampal neurons with gastrodin significantly attenuated Abeta(1-42)-induced neurotoxicity and changes in SOD and CAT, and upregulated gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation. | gastrodin | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 5 | Pre-treatment of primary hippocampal neurons with gastrodin significantly attenuated Abeta(1-42)-induced neurotoxicity and changes in SOD and CAT, and upregulated gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation. | gastrodin | NFE2 like bZIP transcription factor 2 | Rattus norvegicus |
| 6 | Pre-treatment of primary hippocampal neurons with gastrodin significantly attenuated Abeta(1-42)-induced neurotoxicity and changes in SOD and CAT, and upregulated gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation. | gastrodin | mitogen activated protein kinase 3 | Rattus norvegicus |
| 7 | Pre-treatment of primary hippocampal neurons with gastrodin significantly attenuated Abeta(1-42)-induced neurotoxicity and changes in SOD and CAT, and upregulated gene expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) phosphorylation. | gastrodin | mitogen activated protein kinase 3 | Rattus norvegicus |
| 8 | Pharmacological blockade of ERK1/2 abrogation this action of gastrodin. | gastrodin | mitogen activated protein kinase 3 | Rattus norvegicus |
| 9 | The ERK1/2 pathway may be involved in the neuroprotective effect of gastrodin against Abeta(1-42)-induced oxidative in primary cultured rat hippocampal neurons. | gastrodin | mitogen activated protein kinase 3 | Rattus norvegicus |