Title : Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells.

Pub. Date : 2012 Nov

PMID : 22923031






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Valproic acid, a histone deacetylase inhibitor, increases the expression of cell surface MHC class I-related chain molecules (MICs) A and B (MICA and B) in osteosarcoma cells and decreases their secretion of soluble MICA and MICB, which are produced by the proteolytic cleavage of cell surface MICs. Valproic Acid MHC class I polypeptide-related sequence B Homo sapiens