| Protein Name | MHC class I polypeptide-related sequence B |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 4277 |
| Gene Symbol | MICB |
| UniProt | Q29980 (MICB_HUMAN), A0A7D9H7X8 (A0A7D9H7X8_HUMAN), F5H7Q8 (F5H7Q8_HUMAN), A0A0G2JHB5 (A0A0G2JHB5_HUMAN), B7Z8M1 (B7Z8M1_HUMAN), B4DUT9 (B4DUT9_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
51
Total Number of Articles : 54 |
Description |
MHC class I polypeptide-related sequence B |
| Gene Summary |
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
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