PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22403787-0	2012	Chronic nicotine induces hypoxia inducible factor-2alpha in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2.	Nicotine	8-16	potassium inwardly-rectifying channel, subfamily J, member 11	Rattus norvegicus	161-167	
22403787-0	2012	Chronic nicotine induces hypoxia inducible factor-2alpha in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2.	chromaffin	82-92	potassium inwardly-rectifying channel, subfamily J, member 11	Rattus norvegicus	161-167	
22403787-4	2012	Using Western blots, we show that chronic nicotine causes a progressive, time-dependent induction of HIF-2alpha in MAH cells that parallels the upregulation of K(ATP) channel subunit, Kir6.2.	Nicotine	42-50	endothelial PAS domain protein 1	Rattus norvegicus	101-111	
22403787-4	2012	Using Western blots, we show that chronic nicotine causes a progressive, time-dependent induction of HIF-2alpha in MAH cells that parallels the upregulation of K(ATP) channel subunit, Kir6.2.	Nicotine	42-50	potassium inwardly-rectifying channel, subfamily J, member 11	Rattus norvegicus	184-190	
22403787-5	2012	Moreover, a common HIF target, VEGF mRNA, was also upregulated after chronic nicotine.	Nicotine	77-85	vascular endothelial growth factor A	Rattus norvegicus	31-35	
22403787-8	2012	Specificity of this signaling pathway was validated in adrenal glands from pups born to dams exposed to nicotine throughout gestation; the upregulation of both HIF-2alpha and Kir6.2 was confined to medullary, but not cortical, tissue.	Nicotine	104-112	endothelial PAS domain protein 1	Rattus norvegicus	160-170	
22403787-8	2012	Specificity of this signaling pathway was validated in adrenal glands from pups born to dams exposed to nicotine throughout gestation; the upregulation of both HIF-2alpha and Kir6.2 was confined to medullary, but not cortical, tissue.	Nicotine	104-112	potassium inwardly-rectifying channel, subfamily J, member 11	Rattus norvegicus	175-181	
22403787-9	2012	This study has uncovered a signaling pathway whereby a nonhypoxic stimulus (nicotine) promotes HIF-2alpha-mediated transcriptional upregulation of a novel target, Kir6.2 subunit.	Nicotine	76-84	endothelial PAS domain protein 1	Rattus norvegicus	95-105	
22403787-9	2012	This study has uncovered a signaling pathway whereby a nonhypoxic stimulus (nicotine) promotes HIF-2alpha-mediated transcriptional upregulation of a novel target, Kir6.2 subunit.	Nicotine	76-84	potassium inwardly-rectifying channel, subfamily J, member 11	Rattus norvegicus	163-169