Title : Hypoxia inducible factor-2 α is translationally repressed in response to dietary iron deficiency in Sprague-Dawley rats.

Pub. Date : 2011 Sep

PMID : 21753061






3 Functional Relationships(s)
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1 The mRNA for HIF 2-alpha contains an IRE and undergoes iron-dependent regulation in vitro, though the translational regulation of HIF-2alpha in vivo remains unknown. Iron endothelial PAS domain protein 1 Rattus norvegicus
2 Taken together, these results suggest that the translation of HIF-2alpha in the liver is regulated in part by the action of IRP in response to dietary iron deficiency and provide evidence that IRP may assist in coordinating the cellular response to alterations in iron and oxygen status associated with iron deficiency anemia. Iron endothelial PAS domain protein 1 Rattus norvegicus
3 Taken together, these results suggest that the translation of HIF-2alpha in the liver is regulated in part by the action of IRP in response to dietary iron deficiency and provide evidence that IRP may assist in coordinating the cellular response to alterations in iron and oxygen status associated with iron deficiency anemia. Oxygen endothelial PAS domain protein 1 Rattus norvegicus