Pub. Date : 1990 Dec 15
PMID : 2148087
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bradykinin-stimulated prostacyclin synthesis in porcine aortic endothelial cells was enhanced by pretreatment of the cells with pertussis toxin or islet-activating protein (IAP) for 5 hr or longer. | Epoprostenol | islet amyloid polypeptide | Homo sapiens |
| 2 | Bradykinin-stimulated prostacyclin synthesis in porcine aortic endothelial cells was enhanced by pretreatment of the cells with pertussis toxin or islet-activating protein (IAP) for 5 hr or longer. | Epoprostenol | islet amyloid polypeptide | Homo sapiens |
| 3 | Although ADP-ribosylation of a protein with a molecular weight of 41-42 kD in the cell membranes was completed by 3 hr after the addition of IAP into the incubation medium, there was good correlation between enhancement of bradykinin-induced prostacyclin synthesis and ADP-ribosylation of the IAP substrate over a wide range of IAP concentrations. | Epoprostenol | islet amyloid polypeptide | Homo sapiens |
| 4 | Furthermore, even if IAP was removed from the incubation medium at 3 hr, bradykinin-induced prostaglandin synthesis at 24 hr was still potentiated. | Prostaglandins | islet amyloid polypeptide | Homo sapiens |
| 5 | Cycloheximide and actinomycin D enhanced bradykinin-induced prostacyclin synthesis and apparently blocked the effect of IAP. | Cycloheximide | islet amyloid polypeptide | Homo sapiens |
| 6 | Cycloheximide and actinomycin D enhanced bradykinin-induced prostacyclin synthesis and apparently blocked the effect of IAP. | Dactinomycin | islet amyloid polypeptide | Homo sapiens |
| 7 | Since this result suggested the involvement of an inhibitor protein(s) of prostacyclin synthesis in the IAP effect, we studied the effect of IAP on the level of lipocortin I which is known to inhibit phospholipase A2. | Epoprostenol | islet amyloid polypeptide | Homo sapiens |
| 8 | These results suggest that the enhancement of bradykinin-induced prostacyclin synthesis by IAP is associated with a decrease in the level of lipocortin I. | Epoprostenol | islet amyloid polypeptide | Homo sapiens |