PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2148087-0 1990 Enhancement of bradykinin-induced prostacyclin synthesis in porcine aortic endothelial cells by pertussis toxin. Epoprostenol 34-46 kininogen 1 Homo sapiens 15-25 2148087-2 1990 Bradykinin-stimulated prostacyclin synthesis in porcine aortic endothelial cells was enhanced by pretreatment of the cells with pertussis toxin or islet-activating protein (IAP) for 5 hr or longer. Epoprostenol 22-34 kininogen 1 Homo sapiens 0-10 2148087-2 1990 Bradykinin-stimulated prostacyclin synthesis in porcine aortic endothelial cells was enhanced by pretreatment of the cells with pertussis toxin or islet-activating protein (IAP) for 5 hr or longer. Epoprostenol 22-34 islet amyloid polypeptide Homo sapiens 147-171 2148087-2 1990 Bradykinin-stimulated prostacyclin synthesis in porcine aortic endothelial cells was enhanced by pretreatment of the cells with pertussis toxin or islet-activating protein (IAP) for 5 hr or longer. Epoprostenol 22-34 islet amyloid polypeptide Homo sapiens 173-176 2148087-3 1990 Although ADP-ribosylation of a protein with a molecular weight of 41-42 kD in the cell membranes was completed by 3 hr after the addition of IAP into the incubation medium, there was good correlation between enhancement of bradykinin-induced prostacyclin synthesis and ADP-ribosylation of the IAP substrate over a wide range of IAP concentrations. Epoprostenol 242-254 islet amyloid polypeptide Homo sapiens 141-144 2148087-3 1990 Although ADP-ribosylation of a protein with a molecular weight of 41-42 kD in the cell membranes was completed by 3 hr after the addition of IAP into the incubation medium, there was good correlation between enhancement of bradykinin-induced prostacyclin synthesis and ADP-ribosylation of the IAP substrate over a wide range of IAP concentrations. Epoprostenol 242-254 kininogen 1 Homo sapiens 223-233 2148087-4 1990 Furthermore, even if IAP was removed from the incubation medium at 3 hr, bradykinin-induced prostaglandin synthesis at 24 hr was still potentiated. Prostaglandins 92-105 islet amyloid polypeptide Homo sapiens 21-24 2148087-4 1990 Furthermore, even if IAP was removed from the incubation medium at 3 hr, bradykinin-induced prostaglandin synthesis at 24 hr was still potentiated. Prostaglandins 92-105 kininogen 1 Homo sapiens 73-83 2148087-5 1990 Cycloheximide and actinomycin D enhanced bradykinin-induced prostacyclin synthesis and apparently blocked the effect of IAP. Cycloheximide 0-13 kininogen 1 Homo sapiens 41-51 2148087-5 1990 Cycloheximide and actinomycin D enhanced bradykinin-induced prostacyclin synthesis and apparently blocked the effect of IAP. Cycloheximide 0-13 islet amyloid polypeptide Homo sapiens 120-123 2148087-5 1990 Cycloheximide and actinomycin D enhanced bradykinin-induced prostacyclin synthesis and apparently blocked the effect of IAP. Dactinomycin 18-31 kininogen 1 Homo sapiens 41-51 2148087-5 1990 Cycloheximide and actinomycin D enhanced bradykinin-induced prostacyclin synthesis and apparently blocked the effect of IAP. Dactinomycin 18-31 islet amyloid polypeptide Homo sapiens 120-123 2148087-5 1990 Cycloheximide and actinomycin D enhanced bradykinin-induced prostacyclin synthesis and apparently blocked the effect of IAP. Epoprostenol 60-72 kininogen 1 Homo sapiens 41-51 2148087-6 1990 Since this result suggested the involvement of an inhibitor protein(s) of prostacyclin synthesis in the IAP effect, we studied the effect of IAP on the level of lipocortin I which is known to inhibit phospholipase A2. Epoprostenol 74-86 islet amyloid polypeptide Homo sapiens 104-107 2148087-8 1990 These results suggest that the enhancement of bradykinin-induced prostacyclin synthesis by IAP is associated with a decrease in the level of lipocortin I. Epoprostenol 65-77 kininogen 1 Homo sapiens 46-56 2148087-8 1990 These results suggest that the enhancement of bradykinin-induced prostacyclin synthesis by IAP is associated with a decrease in the level of lipocortin I. Epoprostenol 65-77 islet amyloid polypeptide Homo sapiens 91-94