Pub. Date : 2010 Apr 15
PMID : 20178781
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Steroid hormone and insulin/insulin-like growth factor signaling (IIS) pathways control development and lifespan in the nematode Caenorhabditis elegans by regulating the activity of the nuclear receptor DAF-12 and the FoxO transcription factor DAF-16, respectively. | Steroids | Fork-head domain-containing protein;Forkhead box protein O | Caenorhabditis elegans |
| 2 | We identified the 3-beta-hydroxysteroid dehydrogenase (3betaHSD) family member HSD-1, which participates in Delta(4)-DA biosynthesis, as an inhibitor of DAF-16/FoxO activity. | (25S)-Delta(4)-dafachronic acid | Fork-head domain-containing protein;Forkhead box protein O | Caenorhabditis elegans |