PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20178781-1 2010 Steroid hormone and insulin/insulin-like growth factor signaling (IIS) pathways control development and lifespan in the nematode Caenorhabditis elegans by regulating the activity of the nuclear receptor DAF-12 and the FoxO transcription factor DAF-16, respectively. Steroids 0-15 Nuclear hormone receptor family member daf-12 Caenorhabditis elegans 203-209 20178781-1 2010 Steroid hormone and insulin/insulin-like growth factor signaling (IIS) pathways control development and lifespan in the nematode Caenorhabditis elegans by regulating the activity of the nuclear receptor DAF-12 and the FoxO transcription factor DAF-16, respectively. Steroids 0-15 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 244-250 20178781-2 2010 The DAF-12 ligands Delta(4)- and Delta(7)-dafachronic acid (DA) promote bypass of the dauer diapause and proper gonadal migration during larval development; in adults, DAs influence lifespan. delta(4)- 19-28 Nuclear hormone receptor family member daf-12 Caenorhabditis elegans 4-10 20178781-2 2010 The DAF-12 ligands Delta(4)- and Delta(7)-dafachronic acid (DA) promote bypass of the dauer diapause and proper gonadal migration during larval development; in adults, DAs influence lifespan. delta7-dafachronic acid 33-58 Nuclear hormone receptor family member daf-12 Caenorhabditis elegans 4-10 20178781-4 2010 We identified the 3-beta-hydroxysteroid dehydrogenase (3betaHSD) family member HSD-1, which participates in Delta(4)-DA biosynthesis, as an inhibitor of DAF-16/FoxO activity. (25S)-Delta(4)-dafachronic acid 108-119 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase 1 Caenorhabditis elegans 79-84 20178781-4 2010 We identified the 3-beta-hydroxysteroid dehydrogenase (3betaHSD) family member HSD-1, which participates in Delta(4)-DA biosynthesis, as an inhibitor of DAF-16/FoxO activity. (25S)-Delta(4)-dafachronic acid 108-119 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 153-159