PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20025958-3 2010 In this report we have investigated whether phosphoinositide 3-kinase gamma (PI3Kgamma), which is important in inflammatory cell migration, plays a critical role in the neuro-inflammation, synaptic dysfunction, and cognitive deficits induced by intracerebroventricular injection of Abeta(1-40) in mice. UNII-042A8N37WH 282-287 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 44-75 20025958-3 2010 In this report we have investigated whether phosphoinositide 3-kinase gamma (PI3Kgamma), which is important in inflammatory cell migration, plays a critical role in the neuro-inflammation, synaptic dysfunction, and cognitive deficits induced by intracerebroventricular injection of Abeta(1-40) in mice. UNII-042A8N37WH 282-287 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 77-86 20025958-4 2010 We found that the selective inhibitor of PI3Kgamma, AS605240, was able to attenuate the Abeta(1-40)-induced accumulation of activated astrocytes and microglia in the hippocampus, and decrease immuno-staining for p-Akt and cyclooxygenase-2 (COX-2). 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione 52-60 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 41-50 20025958-4 2010 We found that the selective inhibitor of PI3Kgamma, AS605240, was able to attenuate the Abeta(1-40)-induced accumulation of activated astrocytes and microglia in the hippocampus, and decrease immuno-staining for p-Akt and cyclooxygenase-2 (COX-2). 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione 52-60 prostaglandin-endoperoxide synthase 2 Mus musculus 222-238 20025958-4 2010 We found that the selective inhibitor of PI3Kgamma, AS605240, was able to attenuate the Abeta(1-40)-induced accumulation of activated astrocytes and microglia in the hippocampus, and decrease immuno-staining for p-Akt and cyclooxygenase-2 (COX-2). 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione 52-60 prostaglandin-endoperoxide synthase 2 Mus musculus 240-245 20025958-5 2010 Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected. 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione 62-70 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 82-91 20025958-5 2010 Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected. 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione 62-70 tumor necrosis factor Mus musculus 177-204 20025958-5 2010 Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected. 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione 62-70 tumor necrosis factor Mus musculus 206-215 20025958-5 2010 Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected. 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione 62-70 interleukin 1 beta Mus musculus 221-238 20025958-5 2010 Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected. 5-quinoxalin-6-ylmethylenethiazolidine-2,4-dione 62-70 interleukin 1 beta Mus musculus 240-248 20025958-5 2010 Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected. 5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione 103-111 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Mus musculus 82-91 20025958-5 2010 Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected. 5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione 103-111 tumor necrosis factor Mus musculus 177-204 20025958-5 2010 Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected. 5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione 103-111 tumor necrosis factor Mus musculus 206-215 20025958-5 2010 Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected. 5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione 103-111 interleukin 1 beta Mus musculus 221-238 20025958-5 2010 Interestingly, Abeta(1-40) activated macrophages treated with AS605240 or another PI3Kgamma inhibitor, AS252424, displayed impaired chemotaxis in vitro, but their expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) was unaffected. 5-(5-(4-fluoro-2-hydroxyphenyl)furan-2-ylmethylene)thiazolidine-2,4-dione 103-111 interleukin 1 beta Mus musculus 240-248