Pub. Date : 2009 Dec 21
PMID : 19853001
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Up-regulation of CYP1A1 by rutaecarpine is dependent on aryl hydrocarbon receptor and calcium. | rutecarpine | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 2 | In the present study, we investigated the effect of rutaecarpine on CYP1A1 expression mediated by [Ca(2+)] and the AhR pathway in mouse hepatoma Hepa-1c1c7 cells. | rutecarpine | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 3 | Rutaecarpine also significantly increased CYP1A1 enzyme activity and mRNA and protein levels. | rutecarpine | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 4 | Rutaecarpine markedly induced XRE and AhR binding activity. | rutecarpine | aryl-hydrocarbon receptor | Mus musculus |
| 5 | CH-223191, an AhR antagonist, blocked the rutaecarpine-induced CYP1A1 enzyme activity and mRNA and protein expression. | rutecarpine | aryl-hydrocarbon receptor | Mus musculus |
| 6 | CH-223191, an AhR antagonist, blocked the rutaecarpine-induced CYP1A1 enzyme activity and mRNA and protein expression. | rutecarpine | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 7 | W7 and BAPTA/AM, a CaM antagonist and an intracellular Ca(2+) chelator, respectively, blocked the rutaecarpine-induced CYP1A1 enzyme activity and mRNA and protein expression. | rutecarpine | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 8 | These results indicate that rutaecarpine induces CYP1A1 expression through AhR- and calcium-dependent mechanisms. | rutecarpine | cytochrome P450, family 1, subfamily a, polypeptide 1 | Mus musculus |
| 9 | These results indicate that rutaecarpine induces CYP1A1 expression through AhR- and calcium-dependent mechanisms. | rutecarpine | aryl-hydrocarbon receptor | Mus musculus |