Title : Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice.

Pub. Date : 2009 Jul

PMID : 19571405






4 Functional Relationships(s)
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1 The Am80 treatment reduced significantly the insoluble Abeta levels in brain, in particular Abeta(42), while it gave no apparent effects on the soluble Abeta levels. tamibarotene amyloid beta (A4) precursor protein Mus musculus
2 The Am80 treatment reduced significantly the insoluble Abeta levels in brain, in particular Abeta(42), while it gave no apparent effects on the soluble Abeta levels. tamibarotene amyloid beta (A4) precursor protein Mus musculus
3 The Am80 treatment reduced significantly the insoluble Abeta levels in brain, in particular Abeta(42), while it gave no apparent effects on the soluble Abeta levels. tamibarotene amyloid beta (A4) precursor protein Mus musculus
4 The results suggest that oral administration of Am80 may have potency to reduce the extracellular Abeta(42) of insoluble and possibly oligomeric or protofibril forms, which are related to the cause and/or progression of Alzheimer"s disease. tamibarotene amyloid beta (A4) precursor protein Mus musculus