Title : Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes.

Pub. Date : 2008 Dec

PMID : 18809730






2 Functional Relationships(s)
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1 CYP1A2 is generally considered to be the major enzyme involved in the biotransformation of CLZ to its N-demethylated (norCLZ) and N-oxygenated (CLZ N-oxide) metabolites in liver, but several studies have also implicated CYP3A4. clozapine N-oxide cytochrome P450 family 1 subfamily A member 2 Homo sapiens
2 In contrast, the activity of CYP3A4 alone was correlated with the susceptibility of CLZ N-oxide formation to inhibition by these agents. clozapine N-oxide cytochrome P450 family 3 subfamily A member 4 Homo sapiens