Title : Hepatic insulin resistance directly promotes formation of cholesterol gallstones.

Pub. Date : 2008 Jul

PMID : 18587407






1 Functional Relationships(s)
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1 Hepatic insulin resistance also decreases expression of the bile acid synthetic enzymes, particularly Cyp7b1, and produces partial resistance to the farnesoid X receptor, leading to a lithogenic bile salt profile. Bile Acids and Salts cytochrome P450, family 7, subfamily b, polypeptide 1 Mus musculus