Pub. Date : 2008 May 1
PMID : 18374906
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. | Ibuprofen | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |
| 2 | Ibuprofen-treated transgenic mice showed a significant decrease in intraneuronal oligomeric Abeta and hyperphosphorylated tau (AT8) immunoreactivity in the hippocampus. | Ibuprofen | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |
| 3 | Confocal microscopy demonstrated co-localization of conformationally altered (MC1) and early phosphorylated tau (CP-13) with oligomeric Abeta, and less co-localization of oligomeric Abeta and later forms of phosphorylated tau (AT8 and PHF-1) in untreated 3xTg-AD mice. | cp-13 | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |
| 4 | Our findings show that prophylactic treatment of young 3xTg-AD mice with ibuprofen reduces intraneuronal oligomeric Abeta, reduces cognitive deficits, and prevents hyperphosphorylated tau immunoreactivity. | Ibuprofen | histocompatibility 2, class II antigen A, beta 1 | Mus musculus |