Pub. Date : 1991 Apr
PMID : 1706265
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In male rats, hepatic P-450h apoprotein and mRNA decreased to 13% and 24% of control male levels, respectively, within 14 days of STZ injection. | Streptozocin | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 2 | STZ treatment also suppressed P-450h expression in GH-treated hypophysectomized (Hx) male rats, but incompletely. | Streptozocin | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 3 | However, in Hx male rats without GH supplementation, STZ treatment suppressed P-450h apoprotein and mRNA expression to 16% and 6% of nondiabetic Hx male levels, respectively, demonstrating the existence of GH-independent regulation of P-450h expression. | Streptozocin | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 4 | However, in Hx male rats without GH supplementation, STZ treatment suppressed P-450h apoprotein and mRNA expression to 16% and 6% of nondiabetic Hx male levels, respectively, demonstrating the existence of GH-independent regulation of P-450h expression. | Streptozocin | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |
| 5 | The results provide evidence for the existence of STZ-sensitive GH-independent expression of P-450h and further document the gender differences in STZ sensitivity. | Streptozocin | cytochrome P450, subfamily 2, polypeptide 11 | Rattus norvegicus |