Pub. Date : 2006 Dec
PMID : 17009338
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It was reported that paclitaxel is an inhibitor of hepatic P-glycoprotein (P-gp) and hepatic microsomal cytochrome P450 (CYP) 3A1/2, and that naringin is an inhibitor of biliary P-gp and CYP3A1/2 in rats. | naringin | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 2 | It was reported that paclitaxel is an inhibitor of hepatic P-glycoprotein (P-gp) and hepatic microsomal cytochrome P450 (CYP) 3A1/2, and that naringin is an inhibitor of biliary P-gp and CYP3A1/2 in rats. | naringin | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 3 | It was reported that paclitaxel is an inhibitor of hepatic P-glycoprotein (P-gp) and hepatic microsomal cytochrome P450 (CYP) 3A1/2, and that naringin is an inhibitor of biliary P-gp and CYP3A1/2 in rats. | naringin | cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 | Rattus norvegicus |
| 4 | The significantly greater AUC could be due mainly to an inhibition of metabolism of paclitaxel via CYP3A1/2 by oral naringin. | naringin | cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 | Rattus norvegicus |
| 5 | The inhibition of hepatic P-gp by oral naringin could also contribute to the significantly greater AUC of intravenous paclitaxel by oral naringin. | naringin | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |
| 6 | The inhibition of hepatic P-gp by oral naringin could also contribute to the significantly greater AUC of intravenous paclitaxel by oral naringin. | naringin | ATP-binding cassette, subfamily B (MDR/TAP), member 1B | Rattus norvegicus |