Title : Coexpression of NRASQ61R and BRAFV600E in human melanoma cells activates senescence and increases susceptibility to cell-mediated cytotoxicity.

Pub. Date : 2006 Jul 1

PMID : 16818621






1 Functional Relationships(s)
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1 After the first 10 to 12 in vitro passages, the constitutive NRAS(Q61R) transfectant displayed progressive accumulation in G(0)-G(1) phase of the cell cycle and stained for the senescence-associated beta-galactosidase activity (SA-beta-Gal). 2-(2-quinolinyl)-1H-indene--1,3(2H)-dione-6'-sulfonic acid NRAS proto-oncogene, GTPase Homo sapiens