Title : Functional characterization of homo- and heteromeric channel kinases TRPM6 and TRPM7.

Pub. Date : 2006 May

PMID : 16636202






3 Functional Relationships(s)
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1 TRPM6 and TRPM7 are two known channel kinases that play important roles in various physiological processes, including Mg2+ homeostasis. magnesium ion transient receptor potential cation channel subfamily M member 7 Homo sapiens
2 Moreover, micromolar levels of 2-aminoethoxydiphenyl borate (2-APB) maximally increase TRPM6 but significantly inhibit TRPM7 channel activities; whereas millimolar concentrations of 2-APB potentiate TRPM6/7 and TRPM7 channel activities. 2-aminoethoxydiphenyl borate transient receptor potential cation channel subfamily M member 7 Homo sapiens
3 Moreover, micromolar levels of 2-aminoethoxydiphenyl borate (2-APB) maximally increase TRPM6 but significantly inhibit TRPM7 channel activities; whereas millimolar concentrations of 2-APB potentiate TRPM6/7 and TRPM7 channel activities. 2-aminoethoxydiphenyl borate transient receptor potential cation channel subfamily M member 7 Homo sapiens